ARG58344
anti-BCS1L antibody
anti-BCS1L antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections and Human,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes BCS1L |
|---|---|
| Tested Reactivity | Hu, Rat |
| Tested Application | ICC/IF, IHC-P |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | BCS1L |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 33-240 of Human BCS1L (NP_004319.1). |
| Conjugation | Un-conjugated |
| Alternate Names | BCS1; FLNMS; h-BCS; PTD; GRACILE; BCS1-like protein; BJS; Hs.6719; MC3DN1; Mitochondrial chaperone BCS1; h-BCS1; BCS |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 48 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | BCS1L |
| Gene Full Name | BC1 (ubiquinol-cytochrome c reductase) synthesis-like |
| Background | This gene encodes a homolog of the S. cerevisiae bcs1 protein which is involved in the assembly of complex III of the mitochondrial respiratory chain. The encoded protein does not contain a mitochondrial targeting sequence but experimental studies confirm that it is imported into mitochondria. Mutations in this gene are associated with mitochondrial complex III deficiency and the GRACILE syndrome. Five alternatively spliced transcripts encoding the same protein have been described. [provided by RefSeq, Mar 2012] |
| Function | Chaperone necessary for the assembly of mitochondrial respiratory chain complex III. Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. [UniProt] |
| Cellular Localization | Mitochondrion inner membrane, Single-pass membrane protein. [UniProt] |
| Calculated MW | 48 kDa |
