ARG43823
anti-BIM antibody
anti-BIM antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes BIM |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-P, IP, WB |
| Specificity | Human,Mouse,Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | BIM |
| Antigen Species | Human |
| Immunogen | Synthetic peptide of human Bim. |
| Conjugation | Un-conjugated |
| Protein Full Name | Bcl-2-like protein 11 |
| Alternate Names | BCL2L11; BCL2 Like 11; BIM; BOD; BCL2-Like 11 (Apoptosis Facilitator); Bcl-2-Like Protein; BimEL; BimL; BimS; Bcl-2 Interacting Mediator Of Cell Death; Bcl2-Interacting Mediator Of Cell Death; Bcl-2-Related Ovarian Death Agonist; Bcl-2 Interacting Protein Bim; Bcl2-L-11; BAM |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| Observed Size | 22 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity Purified |
| Buffer | Tris-Glycine, 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 40% Glycerol and 0.05% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | BCL2L11 |
| Gene Full Name | BCL2 Like 11 |
| Background | The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013] |
| Function | Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis. [UniProt] |
| Cellular Localization | Membrane, Mitochondrion. [UniProt] |
| Calculated MW | 22 kDa |
| PTM | Phosphoprotein, Ubl conjugation. [UniProt] |
