ARG44785
anti-BLOC1S3 antibody
anti-BLOC1S3 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Mouse Monoclonal antibody recognizes BLOC1S3 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Target Name | BLOC1S3 |
| Antigen Species | Human |
| Epitope | LRRPETVVPG EATETDSERS ASSSEEEELY LGPSGPTRGR PTGLRVAGEA AETDSEPEPE PEPTAAPRDL PPLVVQRESA EEAWGTEEAP APAPARSLLQ LRLAESQARL DHDVAAAVSG |
| Conjugation | Un-conjugated |
| Alternate Names | BLOC1S3; Biogenesis Of Lysosomal Organelles Complex 1 Subunit 3; BLOS3; BLOC-1 Subunit 3; HPS8; Biogenesis Of Lysosome-Related Organelles Complex 1 Subunit 3; Biogenesis Of Lysosome-Related Organelles Complex-1, Subunit 3; Biogenesis Of Lysosome-Related Organelles Complex-1 Subunit 3; Reduced Pigmentation, Mouse, Homolog Of; Hermansky-Pudlak Syndrome 8 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein A purification |
| Buffer | PBS with 0.09% sodium azide |
| Preservative | 0.09% sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | BLOC1S3 |
|---|---|
| Gene Full Name | Biogenesis Of Lysosomal Organelles Complex 1 Subunit 3 |
| Background | This gene encodes a protein that is a component of the BLOC1 multi-subunit protein complex. This complex is necessary for the biogenesis of specialized organelles of the endosomal-lysosomal system, including platelet dense granules and melanosomes. Mutations in this gene cause Hermansky-Pudlak syndrome 8, a disease characterized by lysosomal storage defects, bleeding due to platelet storage pool deficiency, and oculocutaneous albinism. [provided by RefSeq, Jul 2008] |
| Function | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. [Uniprot] |
| Cellular Localization | Cytoplasm. [Uniprot] |
| PTM | Phosphoprotein. [Uniprot] |
