ARG43692
anti-Bcl 11A antibody
anti-Bcl 11A antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Bcl 11A |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Bcl 11A |
| Antigen Species | Human |
| Immunogen | Recombinant fragment corresponding to BCL11A. |
| Conjugation | Un-conjugated |
| Protein Full Name | B-cell lymphoma/leukemia 11A |
| Alternate Names | BCL11A-S; Zinc finger protein 856; BCL11A-XL; HBFQTL5; COUP-TF-interacting protein 1; CTIP1; B-cell lymphoma/leukemia 11A; Ecotropic viral integration site 9 protein homolog; EVI-9; ZNF856; BCL-11A; B-cell CLL/lymphoma 11A; EVI9; BCL11a-M; BCL11A-L |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Positive Control | Ramos | ||||||||
| Observed Size | ~ 100 - 145 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Concentration | Batch dependent |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | BCL11A |
| Gene Full Name | B-cell CLL/lymphoma 11A (zinc finger protein) |
| Background | This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Function | Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. An essential factor in lymphopoiesis, is required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1 (By similarity). [UniProt] |
| Calculated MW | 91 kDa |
| PTM | Sumoylated with SUMO1. [UniProt] |
