ARG10775
anti-Bestrophin 3 antibody
anti-Bestrophin 3 antibody for Confocal microscopy (Confocal),ELISA,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot,Dot blot and Mouse,Rat
Overview
Product Description | Rabbit Polyclonal antibody recognizes Bestrophin 3 |
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Tested Reactivity | Ms, Rat |
Tested Application | Confocal, Dot, ELISA, ICC/IF, IHC-P, IP, WB |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Target Name | Bestrophin 3 |
Antigen Species | Rat |
Immunogen | Synthetic peptide taken within the last 50 aa (C-terminus) from Rat Bestrophin 3. |
Conjugation | Un-conjugated |
Alternate Names | VMD2L3; Bestrophin-3; Vitelliform macular dystrophy 2-like protein 3 |
Application Instructions
Application Suggestion |
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Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
Form | Liquid |
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Purification | Affinity purified. |
Buffer | Tris-Glycine Buffer (pH 7.4 - 7.8), Hepes, 0.02% Sodium azide, 30% Glycerol and 0.5% BSA. |
Preservative | 0.02% Sodium azide |
Stabilizer | 30% Glycerol and 0.5% BSA |
Concentration | 0.5 mg/ml |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links | |
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Gene Symbol | Best3 |
Gene Full Name | bestrophin 3 |
Background | BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002 [PubMed 12032738]; Tsunenari et al., 2003 [PubMed 12907679]).[supplied by OMIM, Mar 2008] |
Function | Forms calcium-sensitive chloride channels. Permeable to bicarbonate. [UniProt] |
Calculated MW | 76 kDa |