ARG40145

anti-C1GALT1C1 / COSMC antibody

anti-C1GALT1C1 / COSMC antibody for Western blot and Human

Overview

Product Description Rabbit Polyclonal antibody recognizes C1GALT1C1 / COSMC
Tested Reactivity Hu
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name C1GALT1C1 / COSMC
Antigen Species Human
Immunogen KLH-conjugated synthetic peptide between aa. 26-60 of Human C1GALT1C1.
Conjugation Un-conjugated
Alternate Names TNPS; C1GalT2; Core 1 beta3-galactosyltransferase-specific molecular chaperone; COSMC; C1GALT2; HSPC067; Core 1 beta3-Gal-T2; Core 1 beta1,3-galactosyltransferase 2; MST143; C1GALT1-specific chaperone 1; C1Gal-T2; C38H2-L1; C38H2-like protein 1

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control HeLa

Properties

Form Liquid
Purification Purification with Protein A and immunogen peptide.
Buffer PBS and 0.09% (W/V) Sodium azide.
Preservative 0.09% (W/V) Sodium azide.
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 29071 Human C1GALT1C1

Swiss-port # Q96EU7 Human C1GALT1-specific chaperone 1

Gene Symbol C1GALT1C1
Gene Full Name C1GALT1-specific chaperone 1
Background This gene encodes a type II transmembrane protein that is similar to the core 1 beta1,3-galactosyltransferase 1, which catalyzes the synthesis of the core-1 structure, also known as Thomsen-Friedenreich antigen, on O-linked glycans. This gene product lacks the galactosyltransferase activity itself, but instead acts as a molecular chaperone required for the folding, stability and full activity of the core 1 beta1,3-galactosyltransferase 1. Mutations in this gene have been associated with Tn syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2009]
Function Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1). [UniProt]
Cellular Localization Membrane; Single-pass type II membrane protein. [UniProt]
Calculated MW 36 kDa