ARG44800
anti-C1orf77 / FOP antibody
anti-C1orf77 / FOP antibody for IHC-Formalin-fixed paraffin-embedded sections and Mouse
Overview
| Product Description | Rat Monoclonal antibody recognizes C1orf77 / FOP |
|---|---|
| Tested Reactivity | Ms |
| Tested Application | IHC-P |
| Host | Rat |
| Clonality | Monoclonal |
| Isotype | IgG2a |
| Target Name | C1orf77 / FOP |
| Antigen Species | Mouse |
| Conjugation | Un-conjugated |
| Alternate Names | CHTOP; Chromatin Target Of PRMT1; SRAG; FOP; C1orf77; Small Protein Rich In Arginine And Glycine; Chromatin Target Of PRMT1 Protein; Friend Of PRMT1 Protein; DKFZP547E1010; Small Arginine- And Glycine-Rich Protein; Chromosome 1 Open Reading Frame 77; Friend Of Prmt1; C10orf77; FL-SRAG; SRAG-3; SRAG-5; Pp7704 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein A purified. |
| Buffer | PBS with 0.09% sodium azide |
| Preservative | 0.09% sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | CHTOP |
|---|---|
| Gene Full Name | Chromatin Target Of PRMT1 |
| Background | This gene encodes a small nuclear protein that is characterized by an arginine and glycine rich region. This protein may have an important role in the regulation of fetal globin gene expression and in the activation of estrogen-responsive genes. A recent study reported that this protein binds 5-hydroxymethylcytosine (5hmC) and associates with an arginine methyltransferase complex (methylosome), which promotes methylation of arginine 3 of histone H4 (H4R3) and activation of genes involved in glioblastomagenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2015] |
| Function | Required for effective mRNA nuclear export and is a component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Stimulates DDX39B ATPase and helicase activities. In cooperation with ALYREF/THOC4 enhances NXF1 RNA binding activity. [Uniprot] |
| Cellular Localization | Nucleus. [Uniprot] |
| PTM | Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation. [Uniprot] |
