ARG22481
anti-C1q antibody (HRP)
anti-C1q antibody (HRP) for ELISA and Human
Overview
| Product Description | HRP-conjugated Sheep Polyclonal antibody recognizes C1q This antibody recognizes human C1q, a sub-component of complement C1. C1q associates with complement components C1r and C1s, which are required for the progression of the proteolytic complement cascade. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis (Troedson et al. 2013).Sheep anti human C1q antibody may cross react with C1q in other species. |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ELISA |
| Host | Sheep |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | C1q |
| Antigen Species | Human |
| Immunogen | Human C1q. |
| Conjugation | HRP |
| Alternate Names | Complement C1q subcomponent subunit B |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS, 0.01% Thiomersal and HRP stabiliser. |
| Preservative | 0.01% Thiomersal |
| Stabilizer | HRP stabiliser |
| Concentration | 1 mg/ml |
| Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P02746 Human Complement C1q subcomponent subunit B |
|---|---|
| Gene Symbol | C1QB |
| Gene Full Name | complement component 1, q subcomponent, B chain |
| Background | This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the B-chain polypeptide of human complement subcomponent C1q [provided by RefSeq, Jul 2008] |
| Function | C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. [UniProt] |
| Calculated MW | 27 kDa |
| PTM | Hydroxylated on lysine and proline residues. Hydroxylated lysine residues can be glycosylated. Human C1Q contains up to 68.3 hydroxylysine-galactosylglucose residues and up to 2.5 hydroxylysine-galactose per molecule. Total percentage hydroxylysine residues glycosylated is 86.4%. |
