ARG24186
anti-C3d antibody
anti-C3d antibody for ELISA,IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Purification by Ion Exchange chromatography. |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ELISA, IHC-P |
| Host | Sheep |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | C3d |
| Antigen Species | Human |
| Immunogen | Purified C3d from human plasma. |
| Conjugation | Un-conjugated |
| Alternate Names | C3; Complement C3; CPAMD1; ARMD9; C3a; C3b; C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 1; Complement Component C3a; Complement Component C3b; Complement Component 3; C3a Anaphylatoxin; Prepro-C3; Epididymis Secretory Sperm Binding Protein Li 62p; Acylation-Stimulating Protein Cleavage Product; HEL-S-62p; AHUS5; ASP |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified C3d from pooled activated serum. |
| Buffer | Glycine buffered saline, 0.1% EACA, 0.09% Sodium azide, 0.01% Benzamidine and 1mM EDTA. |
| Preservative | 0.09% Sodium azide, 0.01% Benzamidine and 1mM EDTA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | C3 |
| Gene Full Name | Complement C3 |
| Background | Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. [provided by RefSeq, Nov 2015] |
| Function | C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates |
| Cellular Localization | Secreted |
| Calculated MW | 187 kDa |
| PTM | Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein, Thioester bond |
