ARG24118
anti-CACNA1C antibody [S57]
anti-CACNA1C antibody [S57] for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Hamster,Rabbit
Cancer antibody; Cell Biology and Cellular Response antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody
Overview
| Product Description | Mouse Monoclonal antibody [S57] recognizes CACNA1C |
|---|---|
| Tested Reactivity | Hu, Ms, Hm, Rb |
| Tested Application | ICC/IF, IHC-P, IP, WB |
| Specificity | Detects ~240kDa |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | S57 |
| Isotype | IgG1 |
| Target Name | CACNA1C |
| Antigen Species | Rabbit |
| Immunogen | Rabbit fusion protein of CACNA1C a.a 1507-1733 |
| Conjugation | Un-conjugated |
| Alternate Names | CCHL1A1; CaV1.2; CACN2; CACNL1A1; TS; Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; Voltage-dependent L-type calcium channel subunit alpha-1C; CACH2; LQT8; Voltage-gated calcium channel subunit alpha Cav1.2 |
Application Instructions
| Application Suggestion |
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS (pH 7.4), 50% Glycerol and 0.09% Sodium azide |
| Preservative | 0.09% Sodium azide |
| Stabilizer | 50% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Full Name | Calcium Voltage-Gated Channel Subunit Alpha1 C |
| Background | This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. [provided by RefSeq, Jul 2008] |
| Research Area | Cancer antibody; Cell Biology and Cellular Response antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody |
| Calculated MW | 249 kDa |
| PTM | Phosphorylation by PKA activates the channel. |
