ARG24119
anti-CACNA1H antibody [N55/10]
anti-CACNA1H antibody [N55/10] for ICC/IF,IHC-Frozen sections,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
Overview
| Product Description | Mouse Monoclonal antibody [N55/10] recognizes CACNA1H |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-Fr, IHC-P, IP, WB |
| Specificity | No cross-reactivity against Cav1.3. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | N55/10 |
| Isotype | IgG1 |
| Target Name | CACNA1H |
| Antigen Species | Human |
| Immunogen | Human fusion protein of CACNA1H |
| Conjugation | Un-conjugated |
| Protein Full Name | Voltage-dependent T-type calcium channel subunit alpha-1H |
| Alternate Names | CACNA1H; Calcium Voltage-Gated Channel Subunit Alpha1 H; Calcium Channel, Voltage-Dependent, T Type, Alpha 1H Subunit; Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1H; Low-Voltage-Activated Calcium Channel Alpha1 3.2 Subunit; Voltage-Gated Calcium Channel Subunit Alpha Cav3.2; Cav3.2; Calcium Channel, Voltage-Dependent, T Type, Alpha 1Hb Subunit; Voltage Dependent T-Type Calcium Channel Alpha-1H Subunit; Low-Voltage-Activated Calcium Channel Alpha13.2 Subunit; Voltage-Gated Calcium Channel Alpha Subunit Cav3.2; Voltage-Gated Calcium Channel Alpha Subunit CavT.2; CACNA1HB; CAV3.2; HALD4; ECA6; EIG6 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS (pH 7.4), 50% Glycerol and 0.09% Sodium azide |
| Preservative | 0.09% Sodium azide |
| Stabilizer | 50% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O95180 Human Voltage-dependent T-type calcium channel subunit alpha-1H Swiss-port # Q9EQ60 Rat Voltage-dependent T-type calcium channel subunit alpha-1H |
|---|---|
| Gene Full Name | Calcium Voltage-Gated Channel Subunit Alpha1 H |
| Background | This gene encodes a T-type member of the alpha-1 subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either encoded by different genes or the result of alternative splicing of transcripts. Alternate transcriptional splice variants, encoding different isoforms, have been characterized for the gene described here. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (CAE). |
| Function | Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation. |
| Cellular Localization | Cell membrane, Membrane |
| Calculated MW | 261 kDa |
| PTM | Glycoprotein |
