ARG54109
anti-CBR1 antibody
anti-CBR1 antibody for ICC/IF,Western blot and Human
Cell Biology and Cellular Response antibody; Metabolism antibody; Signaling Transduction antibody
Overview
| Product Description | Mouse Monoclonal antibody recognizes CBR1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ICC/IF, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Target Name | CBR1 |
| Antigen Species | Human |
| Immunogen | Purified recombinant human CBR1 protein fragments expressed in E.coli |
| Conjugation | Un-conjugated |
| Alternate Names | Short chain dehydrogenase/reductase family 21C member 1; 15-hydroxyprostaglandin dehydrogenase [NADP]; SDR21C1; EC 1.1.1.184; NADPH-dependent carbonyl reductase 1; Prostaglandin-E; CBR; 2; hCBR1; EC 1.1.1.189; Prostaglandin 9-ketoreductase; EC 1.1.1.197; Carbonyl reductase [NADPH] 1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 30 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | PBS (pH 7.4), 0.2% Sodium azide and 50% Glycerol |
| Preservative | 0.2% Sodium azide |
| Stabilizer | 50% Glycerol |
| Concentration | 1.3 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CBR1 |
| Gene Full Name | carbonyl reductase 1 |
| Background | NADPH-dependent reductase with broad substrate specificity.Catalyzes the reduction of a wide variety of carbonyl compounds including quinones,prostaglandins, menadione,plus various xenobiotics.Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha.Can bind glutathione,which explains its higher affinity for glutathione-conjugated substrates.Catalyzes the reduction of S-nitrosoglutathione. |
| Function | NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. [UniProt] |
| Cellular Localization | Cytoplasm |
| Research Area | Cell Biology and Cellular Response antibody; Metabolism antibody; Signaling Transduction antibody |
| Calculated MW | 30 kDa |
