ARG43210
anti-CBX1 / HP1 beta antibody
anti-CBX1 / HP1 beta antibody for Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CBX1 / HP1 beta |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CBX1 / HP1 beta |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 1-185 of Human CBX1 / HP1 beta (NP_006798.1). |
| Conjugation | Un-conjugated |
| Alternate Names | MOD1; Chromobox protein homolog 1; HP1 beta; M31; HP1Hs-beta; Modifier 1 protein; Heterochromatin protein p25; HP1-BETA; Heterochromatin protein 1 homolog beta; CBX; HP1Hsbeta; p25beta |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | OVCAR-3 | ||||
| Observed Size | ~ 25 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CBX1 |
| Gene Full Name | chromobox homolog 1 |
| Background | This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] |
| Function | Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. [UniProt] |
| Cellular Localization | Nucleus. Note=Unassociated with chromosomes during mitosis. [UniProt] |
| Calculated MW | 21 kDa |
| PTM | Not phosphorylated. Ubiquitinated. [UniProt] |
