ARG63843

anti-CBX3 / HP1 gamma antibody

anti-CBX3 / HP1 gamma antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse

Gene Regulation antibody

Overview

Product Description Goat Polyclonal antibody recognizes CBX3 / HP1 gamma
Tested Reactivity Hu, Ms
Predict Reactivity Dog, Rat
Tested Application IHC-P, WB
Specificity No cross-reactivity expected with HP1-alpha and HP1-beta. NP_009207.2 and NP_057671.2 represent same protein.
Host Goat
Clonality Polyclonal
Isotype IgG
Target Name CBX3 / HP1 gamma
Antigen Species Human
Immunogen C-EAFLNSQKAGKEKD
Conjugation Un-conjugated
Alternate Names HP1-GAMMA; Chromobox protein homolog 3; HP1Hs-gamma; HP1 gamma; HECH; Heterochromatin protein 1 homolog gamma; Modifier 2 protein

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P2 - 3 µg/ml
WB0.3 - 1.0 µg/ml
Application Note IHC-P: Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0).
WB: Recommend incubate at RT for 1h.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Buffer Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA
Preservative 0.02% Sodium azide
Stabilizer 0.5% BSA
Concentration 0.5 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 11335 Human CBX3

Swiss-port # Q13185 Human Chromobox protein homolog 3

Background At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011]
Highlight Related products:
CBX3 antibodies; CBX3 Duos / Panels; Anti-Goat IgG secondary antibodies;
Related news:
Senescence Marker Antibody Panel is launched
Research Area Gene Regulation antibody
Calculated MW 21 kDa
PTM Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.