ARG52667

Name: anti-CD10 antibody [SP179]
Brand: arigo Biolaboratories
SKU: ARG52667
Price: 345 USD
Availability: InStock
Rating: 4.5 (2 reviews)

anti-CD10 antibody [SP179]

Ordering Information

Package

Price (USD)

100 μl

345.00

50 μl

239.00

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Datasheet
Review (2)

Overview

Product Description	Rabbit Monoclonal antibody [SP179] recognizes CD10
Tested Reactivity	Hu, Ms, Rat
Tested Application	FACS, IHC-P, WB
Host	Rabbit
Clonality	Monoclonal
Clone	SP179
Isotype	IgG
Target Name	CD10
Antigen Species	Human
Immunogen	Synthetic peptide derived from the N-terminus of human CD10 protein.
Conjugation	Un-conjugated
Alternate Names	Enkephalinase; Neutral endopeptidase; Neutral endopeptidase 24.11; Common acute lymphocytic leukemia antigen; Neprilysin; CD antigen CD10; CALLA; EC 3.4.24.11; CD10; Skin fibroblast elastase; SFE; Atriopeptidase; NEP

Application Instructions

Application Suggestion

Tested Application	Dilution
FACS	Assay-Dependent
IHC-P	1:100
WB	1:400

Application Note

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Positive Control

Kidney, Tonsil, LNCaP Cell Lysate

Properties

Form	Liquid
Purification	Purified by protein A/G
Buffer	PBS (pH 7.6), 1% BSA and < 0.1% Sodium azide
Preservative	< 0.1% Sodium azide
Stabilizer	1% BSA
Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links	GeneID: 17380 Mouse MME GeneID: 24590 Rat MME GeneID: 4311 Human MME Swiss-port # P07861 Rat Neprilysin Swiss-port # P08473 Human Neprilysin Swiss-port # Q61391 Mouse Neprilysin More
Background	CD10 is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. [provided by RefSeq, Aug 2017]
Function	CD10: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573). [UniProt]
Cellular Localization	Membrane
Highlight	Related products: CD10 antibodies; CD10 ELISA Kits; CD10 Duos / Panels; Anti-Rabbit IgG secondary antibodies; Related news: Lymphoma
Research Area	Cancer antibody; Developmental Biology antibody; Immune System antibody
Calculated MW	86 kDa
PTM	Myristoylation is a determinant of membrane targeting. Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity.