ARG21104
anti-CD102 / ICAM2 antibody [3C4] (Biotin)
anti-CD102 / ICAM2 antibody [3C4] (Biotin) for Flow cytometry,IHC-Frozen sections,ICC/IF,Blocking and Mouse
Overview
| Product Description | Biotin-conjugated Rat Monoclonal antibody [3C4] recognizes CD102 / ICAM2 |
|---|---|
| Tested Reactivity | Ms |
| Tested Application | BL, FACS, ICC/IF, IHC-Fr |
| Specificity | Mouse CD102. The clone 3C4 reacts with the cell surface glycoprotein mouse CD102 (ICAM-2), a ligand for the leucocyte integrin CD11a/CD18 (LFA-1). CD102 is constitutively expressed on T cells, B cells, and at high levels on vascular endothelial cells. It is also expressed on a variety of leukocyte cell lines. The 3C4 antibody blocks the interaction between ICAM-2 and LFA-1. |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | 3C4 |
| Isotype | IgG2a, kappa |
| Target Name | CD102 / ICAM2 |
| Antigen Species | Mouse |
| Immunogen | COS cells transfected with mouse ICAM-2 cDNA and BW5147 AKR/J mouse thymoma cell line |
| Conjugation | Biotin |
| Alternate Names | CD102; CD antigen CD102; Intercellular adhesion molecule 2; ICAM-2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Buffer | PBS and 0.1% Sodium azide. |
| Preservative | 0.1% Sodium azide |
| Concentration | 0.5 mg/ml |
| Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | ICAM2 |
| Gene Full Name | intercellular adhesion molecule 2 |
| Background | The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
| Function | ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. [UniProt] |
| Calculated MW | 31 kDa |
