ARG62393

anti-CD105 / Endoglin antibody [105C02]

Ordering Information

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Price (USD)

0.5 ml

355.00

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Overview

Product Description	Mouse Monoclonal antibody [105C02] recognizes CD105 / Endoglin
Tested Reactivity	Hu
Tested Application	FACS, IHC-Fr, IHC-P, WB
Host	Mouse
Clonality	Monoclonal
Clone	105C02
Isotype	IgG1
Target Name	CD105 / Endoglin
Antigen Species	Human
Immunogen	Purified GP160 from cell membrane glycoproteins of fresh non-T/non-B acute lymphoblastic leukemia cells.
Conjugation	Un-conjugated
Alternate Names	CD antigen CD105; HHT1; Endoglin; ORW1; END

Application Instructions

Application Suggestion

Application Note

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Positive Control

HUVEC cells.

Properties

Form	Liquid
Purification	Purified Antibody
Buffer	1X PBS and 0.1% Sodium azide
Preservative	0.1% Sodium azide
Concentration	0.2 mg/ml
Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links	GeneID: 2022 Human ENG Swiss-port # P17813 Human Endoglin
Gene Symbol	ENG
Gene Full Name	endoglin
Background	This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]
Function	Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGF-beta1 signaling through SMAD3. [UniProt]
Research Area	Cancer antibody; Cell Biology and Cellular Response antibody; Controls and Markers antibody; Developmental Biology antibody; Immune System antibody
Calculated MW	71 kDa