ARG54251
anti-CD107a / LAMP1 antibody [H4A3] (PE)
anti-CD107a / LAMP1 antibody [H4A3] (PE) for Flow cytometry and Human,Mouse,Primates
Cancer antibody; Cell Death antibody; Controls and Markers antibody; Developmental Biology antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody; Lysosome Marker antibody
Overview
| Product Description | PE-conjugated Mouse Monoclonal antibody [H4A3] recognizes CD107a / LAMP1 |
|---|---|
| Tested Reactivity | Hu, Ms, NHuPrm |
| Tested Application | FACS |
| Specificity | The mouse monoclonal antibody H4A3 recognizes LAMP1 / CD107a, an approximately 100120 kDa glycoprotein expressed mainly on lysosomal, but also on the plasma membrane. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | H4A3 |
| Isotype | IgG1 |
| Target Name | CD107a / LAMP1 |
| Antigen Species | Human |
| Immunogen | Human PBMC |
| Conjugation | PE |
| Alternate Names | LGP120; CD107a; LAMPA; CD antigen CD107a; Lysosome-associated membrane glycoprotein 1; CD107 antigen-like family member A; LAMP-1; Lysosome-associated membrane protein 1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification Note | The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary. |
| Buffer | PBS, 0.02% Sodium azide and 0.2% (w/v) high-grade protease free BSA |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 0.2% (w/v) high-grade protease free BSA |
| Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P11279 Human Lysosome-associated membrane glycoprotein 1 Swiss-port # P11438 Mouse Lysosome-associated membrane glycoprotein 1 |
|---|---|
| Gene Symbol | LAMP1 |
| Gene Full Name | lysosomal-associated membrane protein 1 |
| Background | CD107a (lysosome-associated membrane protein-1, LAMP-1), together with LAMP-2, is a major constituent of lysosomal membrane, 1-2% of total CD107a is found also on the plasma membrane. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes. Increased CD107a immunoreactivity is observed in neurones, and in glial cells surrounding senile plaques in Alzheimers disease cases and is localized mainly in medullary epithelial cells, single macrophages and lymphocytes in acute thymic involution. CD107a is a good marker of mast cell activation. |
| Function | Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis. [UniProt] |
| Research Area | Cancer antibody; Cell Death antibody; Controls and Markers antibody; Developmental Biology antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody; Lysosome Marker antibody |
| Calculated MW | 45 kDa |
| PTM | O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans. The glycosylation of N-76 is essential for Lassa virus entry into cells. |
Clone References
Cellular mechanisms of toll-like receptor-3 activation in the thalamus are associated with white matter injury in the developing brain.
Induced pluripotent stem cells restore function in a human cell loss model of open-angle glaucoma.
QSOX1 inhibits autophagic flux in breast cancer cells.
ICC/IF / Human
Filamin A promotes dynamin-dependent internalization of hyperpolarization-activated cyclic nucleotide-gated type 1 (HCN1) channels and restricts Ih in hippocampal neurons.
ICC/IF / Rat
Blood-brain barrier impairment in MPS III patients.
IHC-Fr / Human
Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation.
WB / Human
Autophagy in retinal ganglion cells in a rhesus monkey chronic hypertensive glaucoma model.
WB / Rhesus monkey
Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties.
ICC/IF / Mouse
