ARG41506

anti-CD107b / LAMP2A antibody

anti-CD107b / LAMP2A antibody for IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat

Overview

Product Description Rabbit Polyclonal antibody recognizes CD107b / LAMP2A
Tested Reactivity Hu, Ms, Rat
Tested Application IHC-P, IP, WB
Specificity The immunogen sequence was designed to react LAMP2A isoform only (from 370 to 410) and it does not react to LAMP2B and LAMP2C.
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name CD107b / LAMP2a
Antigen Species Human
Immunogen Synthetic peptide between a.a. 370-410 of Human CD107b / LAMP2A (Uniprot ID: P13473-1).
Conjugation Un-conjugated
Alternate Names CD antigen CD107b; LAMPB; CD107b; LGP110; Lysosome-associated membrane glycoprotein 2; LAMP-2; CD107 antigen-like family member B; Lysosome-associated membrane protein 2; LAMP-2A

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P1:50 - 1:200
IP1:50
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control JAR

Properties

Form Liquid
Purification Affinity purified.
Buffer PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 16784 Mouse LAMP2

GeneID: 3920 Human LAMP2

Swiss-port # P13473 Human Lysosome-associated membrane glycoprotein 2

Swiss-port # P17047 Mouse Lysosome-associated membrane glycoprotein 2

Gene Symbol LAMP2
Gene Full Name lysosomal-associated membrane protein 2A
Background The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]
Function Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens. [UniProt]
Cellular Localization Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, autophagosome membrane. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane. [UniProt]
Calculated MW 45 kDa
PTM O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans. [UniProt]