ARG23320
anti-CD130 / gp130 antibody [B-R3] (low endotoxin)
anti-CD130 / gp130 antibody [B-R3] (low endotoxin) for Flow cytometry,ELISA,Functional study and Human
Overview
| Product Description | Azide free and low endotoxin Mouse Monoclonal antibody [B-R3] recognizes CD130 / gp130 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ELISA, FACS, FuncSt |
| Specificity | This antibody recognizes the Gp130, common subunit for IL-6, IL-11, OSM, LIF, CNTF, CT-1 receptors, a 130-140 kDa protein. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | B-R3 |
| Isotype | IgG2a |
| Target Name | CD130 / gp130 |
| Antigen Species | Human |
| Immunogen | Natural soluble gp130 |
| Conjugation | Un-conjugated |
| Alternate Names | CDw130; CD130; CDW130; Interleukin-6 signal transducer; CD antigen CD130; IL-6RB; Membrane glycoprotein 130; GP130; Oncostatin-M receptor subunit alpha; IL-6R subunit beta; Interleukin-6 receptor subunit beta; gp130; IL-6 receptor subunit beta; IL-6R-beta |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification Note | Sterile-filtered through 0.22 µm and treated to remove endotoxins. |
| Buffer | PBS |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P40189 Human Interleukin-6 receptor subunit beta |
|---|---|
| Gene Symbol | IL6ST |
| Gene Full Name | interleukin 6 signal transducer |
| Background | The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014] |
| Function | Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events. [UniProt] |
| Calculated MW | 104 kDa |
| PTM | Phosphorylation of Ser-782 down-regulates cell surface expression. Heavily N-glycosylated (PubMed:11098061, PubMed:16335952, PubMed:19159218, PubMed:19139490, PubMed:11251120). Glycosylation is required for protein stability and localization in plasma membrane but not for ligand binding (PubMed:19915009). [UniProt] |
