ARG23160

anti-CD134 / OX40 antibody [7D6]

anti-CD134 / OX40 antibody [7D6] for Flow cytometry,Western blot and Cat

Overview

Product Description Mouse Monoclonal antibody [7D6] recognizes CD134 / OX40.
Mouse anti Cat CD134 antibody, clone 7D6 recognizes feline CD134, otherwise known as OX40, a 43 kDa type I membrane protein and member of the tumor necrosis factor receptor superfamily, expressed predominantly by CD4+ activated T cells, and a key regulator of T cell-dependent immune responses.CD134 has been identified as the receptor for the OX40 ligand, CD252, expressed by activated B cells, acting as a co-stimulatory signal for the stimulation and secretion of immunoglobulins. CD134 has also been identified as a binding receptor for Feline Immunodeficiency Virus (FIV), acting along with CXC chemokine receptor 4 (CXCR4) to facilitate the entry of the virus into CD4+ primary target cells.
Tested Reactivity Cat
Species Does Not React With Ms
Tested Application FACS, WB
Host Mouse
Clonality Monoclonal
Clone 7D6
Isotype IgG1
Target Name CD134 / OX40
Antigen Species Cat
Immunogen CHO-derived feline CD134-Fc fusion protein.
Conjugation Un-conjugated
Alternate Names CD134; TAX transcriptionally-activated glycoprotein 1 receptor; TXGP1L; OX40L receptor; Tumor necrosis factor receptor superfamily member 4; OX40; CD antigen CD134; IMD16; ACT35 antigen; ACT35

Application Instructions

Application Suggestion
Tested Application Dilution
FACSAssay-dependent
WB1 µg/ml
Application Note FACS: Use 10 µl of the suggested working dilution to label 10^6 cells in 100 µl.
WB: This product detects a band of approximately 43 kDa.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purification with Protein A.
Buffer PBS and 0.09% Sodium azide.
Preservative 0.09% Sodium azide
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Gene Symbol TNFRSF4
Gene Full Name TNF receptor superfamily member 4
Background The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
Function Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity. [UniProt]
Calculated MW 29 kDa