ARG42320

anti-CD134 / OX40 antibody [Ber-ACT35] (APC)

anti-CD134 / OX40 antibody [Ber-ACT35] (APC) for Flow cytometry and Primates,Human

Overview

Product Description APC-conjugated Mouse Monoclonal antibody [Ber-ACT35] recognizes CD134 / OX40
Tested Reactivity Hu, NHuPrm
Tested Application FACS
Specificity The mouse monoclonal antibody Ber-ACT35 (also known as ACT35) recognizes an extracellular epitope of CD134 (TNFRSF4, OX40), an approximately 50 kDa type I transmembrane glycoprotein expressed on activated T cells.
Host Mouse
Clonality Monoclonal
Clone Ber-ACT35
Isotype IgG1, kappa
Target Name CD134 / OX40
Antigen Species Human
Immunogen HTLV 1-transformed HUT-102 cells.
Conjugation APC
Alternate Names CD134; TAX transcriptionally-activated glycoprotein 1 receptor; TXGP1L; OX40L receptor; Tumor necrosis factor receptor superfamily member 4; OX40; CD antigen CD134; IMD16; ACT35 antigen; ACT35

Application Instructions

Application Suggestion
Tested Application Dilution
FACS10 µl / 100 µl of whole blood or 10^6 cells
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purified
Buffer PBS and 15 mM Sodium azide.
Preservative 15 mM Sodium azide
Storage Instruction Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 7293 Human TNFRSF4

Swiss-port # P43489 Human Tumor necrosis factor receptor superfamily member 4

Gene Symbol TNFRSF4
Gene Full Name tumor necrosis factor receptor superfamily, member 4
Background The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
Function Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.

(Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B. [UniProt]
Cellular Localization Membrane; Single-pass type I membrane protein. [UniProt]
Calculated MW 29 kDa