ARG42336
anti-CD134 / OX40 antibody [Ber-ACT35] (PE)
anti-CD134 / OX40 antibody [Ber-ACT35] (PE) for Flow cytometry and Primates,Human
Overview
Product Description | PE-conjugated Mouse Monoclonal antibody [Ber-ACT35] recognizes CD134 / OX40 |
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Tested Reactivity | Hu, NHuPrm |
Tested Application | FACS |
Specificity | The mouse monoclonal antibody Ber-ACT35 (also known as ACT35) recognizes an extracellular epitope of CD134 (TNFRSF4, OX40), an approximately 50 kDa type I transmembrane glycoprotein expressed on activated T cells. |
Host | Mouse |
Clonality | Monoclonal |
Clone | Ber-ACT35 |
Isotype | IgG1, kappa |
Target Name | CD134 / OX40 |
Antigen Species | Human |
Immunogen | HTLV 1-transformed HUT-102 cells. |
Conjugation | PE |
Alternate Names | CD134; TAX transcriptionally-activated glycoprotein 1 receptor; TXGP1L; OX40L receptor; Tumor necrosis factor receptor superfamily member 4; OX40; CD antigen CD134; IMD16; ACT35 antigen; ACT35 |
Application Instructions
Application Suggestion |
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Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
Form | Liquid |
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Purification | Purified |
Buffer | PBS and 15 mM Sodium azide. |
Preservative | 15 mM Sodium azide |
Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links |
Swiss-port # P43489 Human Tumor necrosis factor receptor superfamily member 4 |
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Gene Symbol | TNFRSF4 |
Gene Full Name | tumor necrosis factor receptor superfamily, member 4 |
Background | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008] |
Function | Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity. (Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B. [UniProt] |
Cellular Localization | Membrane; Single-pass type I membrane protein. [UniProt] |
Calculated MW | 29 kDa |