ARG42273

anti-CD137 antibody [4B4-1] (PE)

anti-CD137 antibody [4B4-1] (PE) for Flow cytometry and Human,Primates

Overview

Product Description PE-conjugated Mouse Monoclonal antibody [4B4-1] recognizes CD137
Tested Reactivity Hu, NHuPrm
Tested Application FACS
Specificity The mouse monoclonal antibody 4B4-1 recognizes an extracellular conformational epitope on CD137, an approximately 40 kDa type I transmembrane protein of the TNFR family expressed mainly on activated T cells.
Host Mouse
Clonality Monoclonal
Clone 4B4-1
Isotype IgG1, kappa
Target Name CD137
Antigen Species Human
Immunogen Recombinant Human CD137 ectodomain.
Conjugation PE
Alternate Names ILA; CD137; T-cell antigen 4-1BB homolog; CDw137; T-cell antigen ILA; 4-1BB; CD antigen CD137; Tumor necrosis factor receptor superfamily member 9; 4-1BB ligand receptor

Application Instructions

Application Suggestion
Tested Application Dilution
FACS10 µl / 100 µl of whole blood or 10^6 cells
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purified
Buffer PBS and 15 mM Sodium azide.
Preservative 15 mM Sodium azide
Storage Instruction Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 3604 Human TNFRSF9

Swiss-port # Q07011 Human Tumor necrosis factor receptor superfamily member 9

Gene Symbol TNFRSF9
Gene Full Name tumor necrosis factor receptor superfamily, member 9
Background The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008]
Function Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation. [UniProt]
Cellular Localization Membrane; Single-pass type I membrane protein. [UniProt]
Calculated MW 28 kDa