ARG21004
anti-CD152 / CTLA4 antibody [1B8] (PE)
anti-CD152 / CTLA4 antibody [1B8] (PE) for Flow cytometry,FLISA and Mouse
Overview
Product Description | PE-conjugated Hamster Monoclonal antibody [1B8] recognizes CD152 / CTLA4 |
---|---|
Tested Reactivity | Ms |
Tested Application | FACS, FLISA |
Specificity | Mouse CD152. |
Host | Hamster |
Clonality | Monoclonal |
Clone | 1B8 |
Isotype | IgG1 |
Target Name | CD152 / CTLA4 |
Antigen Species | Mouse |
Immunogen | Extracellular portion of murine CTLA-4 fused to a murine IgG2a |
Conjugation | PE |
Alternate Names | GRD4; CTLA-4; CELIAC3; CD; Cytotoxic T-lymphocyte-associated antigen 4; CD152; GSE; CD antigen CD152; Cytotoxic T-lymphocyte protein 4; ALPS5; IDDM12 |
Application Instructions
Application Suggestion |
|
||||||
---|---|---|---|---|---|---|---|
Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
Form | Liquid |
---|---|
Buffer | PBS, 0.1% Sodium azide and Sucrose. |
Preservative | 0.1% Sodium azide |
Stabilizer | Sucrose |
Concentration | 0.1 mg/ml |
Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links | |
---|---|
Gene Symbol | CTLA4 |
Gene Full Name | cytotoxic T-lymphocyte-associated protein 4 |
Background | This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008] |
Function | Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. [UniProt] |
Calculated MW | 25 kDa |
PTM | N-glycosylation is important for dimerization. Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface. |