ARG42650

anti-CD153 / CD30 Ligand antibody

anti-CD153 / CD30 Ligand antibody for IHC-Formalin-fixed paraffin-embedded sections,Flow cytometry and Human

Overview

Product Description Rabbit Polyclonal antibody recognizes CD153 / CD30 Ligand
Tested Reactivity Hu
Tested Application FACS, IHC-P
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name CD153 / CD30 Ligand
Antigen Species Human
Immunogen Recombinant protein corresponding to Q63-D234 of Human CD153 / CD30 Ligand.
Conjugation Un-conjugated
Alternate Names Tumor necrosis factor ligand superfamily member 8; CD30L; CD30-L; CD153; CD antigen CD153; CD30LG; CD30 ligand

Application Instructions

Application Suggestion
Tested Application Dilution
FACS1:150 - 1:500
IHC-P1:200 - 1:1000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Affinity purification with immunogen.
Buffer 0.2% Na2HPO4, 0.9% NaCl, 0.05% Sodium azide and 5% BSA.
Preservative 0.05% Sodium azide
Stabilizer 5% BSA
Concentration 0.5 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 944 Human TNFSF8

Swiss-port # P32971 Human Tumor necrosis factor ligand superfamily member 8

Gene Symbol TNFSF8
Gene Full Name tumor necrosis factor (ligand) superfamily, member 8
Background The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Function Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells. [UniProt]
Cellular Localization Membrane; Single-pass type II membrane protein. [UniProt]
Calculated MW 26 kDa