ARG65427

anti-CD160 antibody [BY55]

anti-CD160 antibody [BY55] for Flow cytometry,Immunoprecipitation and Human

Immune System antibody

Overview

Product Description Mouse Monoclonal antibody [BY55] recognizes CD160
Tested Reactivity Hu
Tested Application FACS, IP
Specificity The clone BY55 recognizes CD160, a 27 kDa glycoprotein expressed on NK cells, NK-T cells, intestinal intraepithelial lymphocytes, TCR-gamma/delta T cells and a small population of TCR-alpha/beta T cells. detects both GPI-anchored and transmembrane form of CD160.
Host Mouse
Clonality Monoclonal
Clone BY55
Isotype IgM
Target Name CD160
Antigen Species Human
Immunogen Human NK cell line YT2C2
Conjugation Un-conjugated
Alternate Names BY55; Natural killer cell receptor BY55; NK28; NK1; CD antigen CD160; CD160 antigen

Application Instructions

Application Suggestion
Tested Application Dilution
FACS1 - 4 µg/ml
IPAssay-dependent
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purified from cell culture supernatant by precipitation and ion exchange chromatography.
Purity > 95% (by SDS-PAGE)
Buffer TBS (pH 8.0) and 15 mM Sodium azide
Preservative 15 mM Sodium azide
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 11126 Human CD160

Swiss-port # O95971 Human CD160 antigen

Gene Symbol CD160
Gene Full Name CD160 molecule
Background CD160 is a cell surface glycoprotein of immunoglobulin superfamily, which functions as a costimulatory receptor expressed mainly on cytotoxic cell populations and recognizing both classical and non-classical MHC class I molecules. It can form disulfide-linked multimers. Down-modulation of CD160 occurs as a consequence of its proteolytic cleavage and the released soluble form was found to impair the MHC-class I specific cytotoxicity of CD8+ T lymphocytes and NK cells. In contrast to GPI-anchored isoform with broader expression among CD160 positive cells, expression of the transmembrane isoform is restricted to NK cells and is activation-dependent.
Function Receptor showing broad specificity for both classical and non-classical MHC class I molecules. [UniProt]
Research Area Immune System antibody
Calculated MW 20 kDa

Clone References

A novel 80-kD cell surface structure identifies human circulating lymphocytes with natural killer activity.

Maïza H et al.
J Exp Med.,  (1993)

publication_link

 

hr_line