ARG65427
anti-CD160 antibody [BY55]
anti-CD160 antibody [BY55] for Flow cytometry,Immunoprecipitation and Human
Immune System antibody
Overview
| Product Description | Mouse Monoclonal antibody [BY55] recognizes CD160 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS, IP |
| Specificity | The clone BY55 recognizes CD160, a 27 kDa glycoprotein expressed on NK cells, NK-T cells, intestinal intraepithelial lymphocytes, TCR-gamma/delta T cells and a small population of TCR-alpha/beta T cells. detects both GPI-anchored and transmembrane form of CD160. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | BY55 |
| Isotype | IgM |
| Target Name | CD160 |
| Antigen Species | Human |
| Immunogen | Human NK cell line YT2C2 |
| Conjugation | Un-conjugated |
| Alternate Names | BY55; Natural killer cell receptor BY55; NK28; NK1; CD antigen CD160; CD160 antigen |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified from cell culture supernatant by precipitation and ion exchange chromatography. |
| Purity | > 95% (by SDS-PAGE) |
| Buffer | TBS (pH 8.0) and 15 mM Sodium azide |
| Preservative | 15 mM Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CD160 |
| Gene Full Name | CD160 molecule |
| Background | CD160 is a cell surface glycoprotein of immunoglobulin superfamily, which functions as a costimulatory receptor expressed mainly on cytotoxic cell populations and recognizing both classical and non-classical MHC class I molecules. It can form disulfide-linked multimers. Down-modulation of CD160 occurs as a consequence of its proteolytic cleavage and the released soluble form was found to impair the MHC-class I specific cytotoxicity of CD8+ T lymphocytes and NK cells. In contrast to GPI-anchored isoform with broader expression among CD160 positive cells, expression of the transmembrane isoform is restricted to NK cells and is activation-dependent. |
| Function | Receptor showing broad specificity for both classical and non-classical MHC class I molecules. [UniProt] |
| Research Area | Immune System antibody |
| Calculated MW | 20 kDa |
Clone References
A novel 80-kD cell surface structure identifies human circulating lymphocytes with natural killer activity.
