ARG54231

anti-CD160 antibody [BY55] (PE)

anti-CD160 antibody [BY55] (PE) for Flow cytometry and Human

Immune System antibody

Overview

Product Description PE-conjugated Mouse Monoclonal antibody [BY55] recognizes CD160
Tested Reactivity Hu
Tested Application FACS
Specificity The clone BY55 recognizes CD160, a 27 kDa glycoprotein expressed on NK cells, NK-T cells, intestinal intraepithelial lymphocytes, TCR-gamma/delta T cells and a small population of TCR-alpha/beta T cells. detects both GPI-anchored and transmembrane form of CD160.
Host Mouse
Clonality Monoclonal
Clone BY55
Isotype IgM
Target Name CD160
Antigen Species Human
Immunogen Human NK cell line YT2C2
Conjugation PE
Alternate Names BY55; Natural killer cell receptor BY55; NK28; NK1; CD antigen CD160; CD160 antigen

Application Instructions

Application Suggestion
Tested Application Dilution
FACS10 µl / 10^6 cells
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Note The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.
Buffer TBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA
Preservative 15 mM Sodium azide
Stabilizer 0.2% (w/v) high-grade protease free BSA
Storage Instruction Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 11126 Human CD160

Swiss-port # O95971 Human CD160 antigen

Gene Symbol CD160
Gene Full Name CD160 molecule
Background CD160 is a cell surface glycoprotein of immunoglobulin superfamily, which functions as a costimulatory receptor expressed mainly on cytotoxic cell populations and recognizing both classical and non-classical MHC class I molecules. It can form disulfide-linked multimers. Down-modulation of CD160 occurs as a consequence of its proteolytic cleavage and the released soluble form was found to impair the MHC-class I specific cytotoxicity of CD8+ T lymphocytes and NK cells. In contrast to GPI-anchored isoform with broader expression among CD160 positive cells, expression of the transmembrane isoform is restricted to NK cells and is activation-dependent.
Function Receptor showing broad specificity for both classical and non-classical MHC class I molecules. [UniProt]
Research Area Immune System antibody
Calculated MW 20 kDa

Clone References

A novel 80-kD cell surface structure identifies human circulating lymphocytes with natural killer activity.

Maïza H et al.
J Exp Med.,  (1993)

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