ARG54231
anti-CD160 antibody [BY55] (PE)
anti-CD160 antibody [BY55] (PE) for Flow cytometry and Human
Immune System antibody
Overview
Product Description | PE-conjugated Mouse Monoclonal antibody [BY55] recognizes CD160 |
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Tested Reactivity | Hu |
Tested Application | FACS |
Specificity | The clone BY55 recognizes CD160, a 27 kDa glycoprotein expressed on NK cells, NK-T cells, intestinal intraepithelial lymphocytes, TCR-gamma/delta T cells and a small population of TCR-alpha/beta T cells. detects both GPI-anchored and transmembrane form of CD160. |
Host | Mouse |
Clonality | Monoclonal |
Clone | BY55 |
Isotype | IgM |
Target Name | CD160 |
Antigen Species | Human |
Immunogen | Human NK cell line YT2C2 |
Conjugation | PE |
Alternate Names | BY55; Natural killer cell receptor BY55; NK28; NK1; CD antigen CD160; CD160 antigen |
Application Instructions
Application Suggestion |
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Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
Form | Liquid |
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Purification Note | The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary. |
Buffer | TBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA |
Preservative | 15 mM Sodium azide |
Stabilizer | 0.2% (w/v) high-grade protease free BSA |
Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links | |
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Gene Symbol | CD160 |
Gene Full Name | CD160 molecule |
Background | CD160 is a cell surface glycoprotein of immunoglobulin superfamily, which functions as a costimulatory receptor expressed mainly on cytotoxic cell populations and recognizing both classical and non-classical MHC class I molecules. It can form disulfide-linked multimers. Down-modulation of CD160 occurs as a consequence of its proteolytic cleavage and the released soluble form was found to impair the MHC-class I specific cytotoxicity of CD8+ T lymphocytes and NK cells. In contrast to GPI-anchored isoform with broader expression among CD160 positive cells, expression of the transmembrane isoform is restricted to NK cells and is activation-dependent. |
Function | Receptor showing broad specificity for both classical and non-classical MHC class I molecules. [UniProt] |
Research Area | Immune System antibody |
Calculated MW | 20 kDa |