ARG22871

anti-CD169 / Siglec 1 antibody [3D6.112] (FITC)

anti-CD169 / Siglec 1 antibody [3D6.112] (FITC) for Flow cytometry and Mouse

Overview

Product Description FITC-conjugated Rat Monoclonal antibody [3D6.112] recognizes CD169 / Siglec 1
Tested Reactivity Ms
Tested Application FACS
Host Rat
Clonality Monoclonal
Clone 3D6.112
Isotype IgG2a
Target Name CD169 / Siglec 1
Antigen Species Mouse
Immunogen Purified murine sialoadhesin.
Conjugation FITC
Alternate Names CD169; Siglec-1; dJ1009E24.1; Sialic acid-binding Ig-like lectin 1; SIGLEC-1; CD antigen CD169; SN; Sialoadhesin

Application Instructions

Application Suggestion
Tested Application Dilution
FACS1:100 - 1:1000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purification with Protein G.
Buffer PBS, 0.09% Sodium azide and 1% BSA
Preservative 0.09% Sodium azide
Stabilizer 1% BSA
Concentration 0.1 mg/ml
Storage Instruction Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 20612 Mouse SIGLEC1

Swiss-port # Q62230 Mouse Sialoadhesin

Gene Symbol Siglec1
Gene Full Name sialic acid binding Ig-like lectin 1, sialoadhesin
Background This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]
Function Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis. [UniProt]
Calculated MW 183 kDa