ARG42302
anti-CD169 / Siglec 1 antibody [7-239] (APC)
anti-CD169 / Siglec 1 antibody [7-239] (APC) for Flow cytometry and Human
Overview
Product Description | APC-conjugated Mouse Monoclonal antibody [7-239] recognizes CD169 / Siglec 1 |
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Tested Reactivity | Hu |
Tested Application | FACS |
Specificity | The mouse monoclonal antibody 7-239 recognizes an extracellular epitope of CD169 (sialoadhesin, Siglec-1), a 210 kDa type I transmembrane glycoprotein expressed on macrophages and dendritic cells. |
Host | Mouse |
Clonality | Monoclonal |
Clone | 7-239 |
Isotype | IgG1 |
Target Name | CD169 / Siglec 1 |
Antigen Species | Human |
Immunogen | Human rhinovirus 14-infected monocyte-derived dendritic cells. |
Conjugation | APC |
Alternate Names | CD169; Siglec-1; dJ1009E24.1; Sialic acid-binding Ig-like lectin 1; SIGLEC-1; CD antigen CD169; SN; Sialoadhesin |
Application Instructions
Application Suggestion |
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Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
Form | Liquid |
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Purification | Purified |
Buffer | PBS and 15 mM Sodium azide. |
Preservative | 15 mM Sodium azide |
Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links | |
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Gene Symbol | SIGLEC1 |
Gene Full Name | sialic acid binding Ig-like lectin 1, sialoadhesin |
Background | This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008] |
Function | Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis. [UniProt] |
Cellular Localization | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. [UniProt] |
Calculated MW | 183 kDa |