ARG22873
anti-CD169 / Siglec 1 antibody [MOMA-1]
anti-CD169 / Siglec 1 antibody [MOMA-1] for IHC-Frozen sections,Flow cytometry,ICC/IF and Mouse
Overview
Product Description | Rat Monoclonal antibody [MOMA-1] recognizes CD169 / Siglec 1 |
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Tested Reactivity | Ms |
Species Does Not React With | Hu, Rat |
Tested Application | FACS, ICC/IF, IHC-Fr |
Host | Rat |
Clonality | Monoclonal |
Clone | MOMA-1 |
Isotype | IgG2a |
Target Name | CD169 / Siglec 1 |
Antigen Species | Mouse |
Immunogen | Stromal (reticular) elements from Mouse lymph nodes. |
Conjugation | Un-conjugated |
Alternate Names | CD169; Siglec-1; dJ1009E24.1; Sialic acid-binding Ig-like lectin 1; SIGLEC-1; CD antigen CD169; SN; Sialoadhesin |
Application Instructions
Application Suggestion |
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Application Note | FACS: Use 10 µl of the suggested working dilution to label 10^6 cells in 100 µl * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
Form | Liquid |
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Purification | Purification with Protein G. |
Buffer | PBS and 0.09% Sodium azide |
Preservative | 0.09% Sodium azide |
Concentration | 1 mg/ml |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links | |
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Gene Symbol | Siglec1 |
Gene Full Name | sialic acid binding Ig-like lectin 1, sialoadhesin |
Background | This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008] |
Function | Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis. [UniProt] |
Calculated MW | 183 kDa |