ARG23876

anti-CD192 / CCR2 antibody

anti-CD192 / CCR2 antibody for ELISA,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human

Overview

Product Description Goat Polyclonal antibody recognizes CD192 / CCR2 antibody
Tested Reactivity Hu
Tested Application ELISA, IHC-P, WB
Host Goat
Clonality Polyclonal
Isotype IgG
Target Name CD192 / CCR2
Antigen Species Human
Immunogen Synthetic peptide corresponding to aa. 17-39 of Human CD192 / CCR2. (C-GEEVTTFFDYDYGAPCHKFDVKQ)
Conjugation Un-conjugated
Alternate Names CCR2B; CD192; CKR2; Monocyte chemoattractant protein 1 receptor; CCR-2; CKR2B; CKR2A; CMKBR2; CCR2; C-C CKR-2; CC-CKR-2; CD antigen CD192; MCP-1-R; CCR2A; C-C chemokine receptor type 2

Application Instructions

Application Suggestion
Tested Application Dilution
ELISA1:30000
IHC-P1:100
WB1:500
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Spleen tissue.

Properties

Form Liquid
Purification Affinity purification with immunogen.
Buffer PBS, 0.1% Sodium azide and 0.1% BSA.
Preservative 0.1% Sodium azide
Stabilizer 0.1% BSA
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 729230 Human CCR2

Swiss-port # P41597 Human C-C chemokine receptor type 2

Gene Symbol CCR2
Gene Full Name chemokine (C-C motif) receptor 2
Background This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009]
Function Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection. [UniProt]
Cellular Localization Cell membrane; Multi-pass membrane protein. Note=The chemoattractant receptors are distributed throughout the cell surface; after stimulation with a ligand, such as CCL2, they are rapidly recruited into microdomain clusters at the cell membrane. [UniProt]
Calculated MW 42 kDa
PTM N-glycosylated.

Sulfation increases the affinity for both monomeric and dimeric CCL2 with stronger binding to the monomeric form. Binding of sulfated CCR2 to CCL2 promotes conversion of CCL2 from dimer to monomer. [UniProt]