ARG23105
anti-CD1a antibody [NA1/34-HLK]
anti-CD1a antibody [NA1/34-HLK] for IHC-Frozen sections,Flow cytometry and Human,Dog,Monkey
Overview
| Product Description | Mouse Monoclonal antibody [NA1/34-HLK] recognizes CD1a Mouse anti Human CD1a antibody, clone NA1/34-HLK recognizes the human CD1a cell surface glycoprotein, a ~49kDa single pass type 1 transmembrane glycoprotein containing a single Ig-like domain, expressed in association with beta 2 microglobulin. CD1a is expressed strongly by cortical thymocytes, and also by Langerhans cells and interdigitating cells. CD1a is involved in the presentation of lipids and glycolipids to NK cells (Sloma et al. 2008).Mouse anti Human CD1a, clone NA1/34-HLK is routinely tested in flow cytometry on MOLT4 cells. |
|---|---|
| Tested Reactivity | Hu, Dog, Mk |
| Tested Application | FACS, IHC-Fr |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | NA1/34-HLK |
| Isotype | IgG2a |
| Target Name | CD1a |
| Antigen Species | Human |
| Immunogen | Human thymocytes |
| Conjugation | Un-conjugated |
| Alternate Names | R4; FCB6; CD antigen CD1a; T6; T-cell surface antigen T6/Leu-6; hTa1 thymocyte antigen; T-cell surface glycoprotein CD1a; CD1; HTA1 |
Application Instructions
| Application Suggestion |
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| Application Note | FACS: Use 10 µl of the suggested working dilution to label 10^6 cells in 100 µl. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified by ion exchange chromatography. |
| Buffer | PBS and 0.09% Sodium azide |
| Preservative | 0.09% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CD1A |
| Gene Full Name | CD1a molecule |
| Background | This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] |
| Function | Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. [UniProt] |
| Highlight | Related products: CD1a antibodies; Anti-Mouse IgG secondary antibodies; Related news: Detecting exosomal HMGB1 for ICD research |
| Calculated MW | 37 kDa |
