ARG65474

anti-CD1c antibody [L161]

anti-CD1c antibody [L161] for Flow cytometry,Immunohistochemistry,Immunoprecipitation,CyTOF®-candidate and Human

Immune System antibody

Overview

Product Description Mouse Monoclonal antibody [L161] recognizes CD1c
Tested Reactivity Hu
Tested Application CyTOF®-candidate, FACS, IHC, IP
Specificity The clone L161 recognizes CD1c, (R7), a 43 kDa type I glycoprotein associated with beta2-microglobulin. It is expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells, B and some T cells.
Host Mouse
Clonality Monoclonal
Clone L161
Isotype IgG1
Target Name CD1c
Antigen Species Human
Immunogen human thymocytes
Conjugation Un-conjugated
Alternate Names R7; CD antigen CD1c; CD1A; CD1; T-cell surface glycoprotein CD1c; BDCA1

Application Instructions

Application Suggestion
Tested Application Dilution
CyTOF®-candidateAssay-dependent
FACS1 - 4 µg/ml
IHCAssay-dependent
IPAssay-dependent
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purified from cell culture supernatant by protein-A affinity chromatography.
Purity > 95% (by SDS-PAGE)
Buffer PBS (pH 7.4) and 15 mM Sodium azide
Preservative 15 mM Sodium azide
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 911 Human CD1C

Swiss-port # P29017 Human T-cell surface glycoprotein CD1c

Gene Symbol CD1C
Gene Full Name CD1c molecule
Background CD1c (also known as R7 or BDCA1) together with CD1a and b, belongs to group 1 of CD1 antigens. These non-classical MHC-like glycoproteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. The trafficking routes of the particular CD1 types differ and correspond to their ability to bind and present different groups of antigens. CD1c is unique in its ability to present e.g. mycobacterial phosphoketides and polyisoprenoids. CD1c is the only CD1 isoform that has been shown to interact both with alpha/beta and gamma/delta T cells.
Function Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. [UniProt]
Highlight Related products:
CD1c antibodies; Anti-Mouse IgG secondary antibodies;
Related news:
CyTOF-candidate Antibodies
Research Area Immune System antibody
Calculated MW 38 kDa