ARG54293
anti-CD200 antibody [OX-104] (PE)
anti-CD200 antibody [OX-104] (PE) for Flow cytometry and Human
Cell Biology and Cellular Response antibody; Immune System antibody
Overview
Product Description | PE-conjugated Mouse Monoclonal antibody [OX-104] recognizes CD200 |
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Tested Reactivity | Hu |
Tested Application | FACS |
Specificity | The clone OX-104 recognizes CD200, a type-1 glycoprotein of the immunoglobulin superfamily, which is expressed in neurons, B and T cell subsets, keratinocytes, follicular dendritic cells, and ovarian cells. |
Host | Mouse |
Clonality | Monoclonal |
Clone | OX-104 |
Isotype | IgG1 |
Target Name | CD200 |
Antigen Species | Human |
Immunogen | Human CD200 |
Conjugation | PE |
Alternate Names | OX-2; OX-2 membrane glycoprotein; MOX1; MOX2; CD antigen CD200; MRC |
Application Instructions
Application Suggestion |
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Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
Form | Liquid |
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Purification Note | The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary. |
Buffer | PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA |
Preservative | 15 mM Sodium azide |
Stabilizer | 0.2% (w/v) high-grade protease free BSA |
Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links | |
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Gene Symbol | CD200 |
Gene Full Name | CD200 molecule |
Background | CD200 (also known as OX2 or MRC) is a type-1 membrane glycoprotein, which contains two extracellular immunoglobulin domains, transmembrane domain and cytoplasmic domain. It is expressed by neuronal cells, B and T cell subsets, follicular dendritic cells, keratinocytes, and ovarian cells. The interaction between CD200 and its receptor CD200R results in macrophage activation (IL-6 production), inhibition of mast cell degranulation along with reduced TNF-alpha and IL-13 secretion and overall attenuation of the activation status of lymphocytes. It seems CD200 is also involved in maternal tolerance and its decreased expression in hair follicle correlates with follicular miniaturization. |
Function | Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues. [UniProt] |
Research Area | Cell Biology and Cellular Response antibody; Immune System antibody |
Calculated MW | 31 kDa |
Clone References