ARG59260

anti-CD201 / EPCR antibody

anti-CD201 / EPCR antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Rat

Overview

Product Description Rabbit Polyclonal antibody recognizes CD201 / EPCR
Tested Reactivity Hu, Rat
Predict Reactivity Ms
Tested Application IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name CD201 / EPCR
Antigen Species Human
Immunogen Recombinant fusion protein corresponding to aa. 19-209 of Human CD201 / EPCR (NP_006395.2).
Conjugation Un-conjugated
Alternate Names CD antigen CD201; Activated protein C receptor; EPCR; APC receptor; CCCA; Endothelial cell protein C receptor; CCD41; Endothelial protein C receptor

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P1:50 - 1:200
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control THP-1
Observed Size 50 kDa

Properties

Form Liquid
Purification Affinity purified.
Buffer PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 10544 Human PROCR

GeneID: 362248 Rat PROCR

Swiss-port # Q4V8I1 Rat Endothelial protein C receptor

Swiss-port # Q9UNN8 Human Endothelial protein C receptor

Gene Symbol PROCR
Gene Full Name protein C receptor, endothelial
Background The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013]
Function Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation. [UniProt]
Cellular Localization Membrane; Single-pass type I membrane protein. [UniProt]
Calculated MW 27 kDa
PTM N-glycosylated.

A soluble form exists; probably released by a metalloprotease. Seems to have the same activity as the membrane-bound form. [UniProt]