ARG42334

anti-CD206 / MMR antibody [15-2] (FITC)

anti-CD206 / MMR antibody [15-2] (FITC) for Flow cytometry and Human

Overview

Product Description FITC-conjugated Mouse Monoclonal antibody [15-2] recognizes CD206 / MMR
Tested Reactivity Hu
Tested Application FACS
Specificity The mouse monoclonal antibody 15-2 (also known as MR15-2) recognizes an extracellular epitope of CD206 (macrophage mannose receptor, MMR), a 162-175 kDa type I transmembrane protein expressed mainly on macrophages, dendritic cells and hepatic or lymphatic endothelial cells, but not on monocytes.
Host Mouse
Clonality Monoclonal
Clone 15-2
Isotype IgG1, kappa
Target Name CD206 / MMR
Antigen Species Human
Immunogen Purified Human MMR.
Conjugation FITC
Alternate Names CLEC13D; C-type lectin domain family 13 member D; Macrophage mannose receptor 1-like protein 1; C-type lectin domain family 13 member D-like; MMR; CLEC13DL; CD206; Macrophage mannose receptor 1; bA541I19.1; CD antigen CD206; MRC1L1

Application Instructions

Application Suggestion
Tested Application Dilution
FACS4 µl / 100 µl of whole blood or 10^6 cells
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purified
Buffer PBS and 15 mM Sodium azide.
Preservative 15 mM Sodium azide
Storage Instruction Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 4360 Human MRC1

Swiss-port # P22897 Human Macrophage mannose receptor 1

Gene Symbol MRC1
Gene Full Name mannose receptor, C type 1
Background The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. [provided by RefSeq, Sep 2015]
Function Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.

(Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens.

(Microbial infection) Acts as a receptor for Dengue virus envelope protein E.

(Microbial infection) Interacts with Hepatitis B virus envelope protein. [UniProt]
Cellular Localization Endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. [UniProt]
Highlight Related products:
CD206 antibodies; CD206 ELISA Kits; CD206 Duos / Panels; Anti-Mouse IgG secondary antibodies;
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Calculated MW 166 kDa