ARG55633

anti-CD206 / MMR antibody [15-2] (PE)

anti-CD206 / MMR antibody [15-2] (PE) for Flow cytometry and Human,Mouse

Immune System antibody; M1/M2/TAM Marker antibody; Macrophage Marker antibody; M2 Macrophage Marker antibody

Overview

Product Description PE-conjugated Mouse Monoclonal antibody [15-2] recognizes CD206 / MMR
Tested Reactivity Hu, Ms
Tested Application FACS
Specificity This antibody recognizes CD206 (macrophage mannose receptor, MMR), a 162-175 kDa type I transmembrane protein expressed mainly on macrophages, dendritic cells and hepatic or lymphatic endothelial cells, but not on monocytes.
Host Mouse
Clonality Monoclonal
Clone 15-2
Isotype IgG1
Target Name CD206 / MMR
Antigen Species Human
Immunogen Purified Human CD206 / MMR (NP_002429.1).
Conjugation PE
Alternate Names CLEC13D; C-type lectin domain family 13 member D; Macrophage mannose receptor 1-like protein 1; C-type lectin domain family 13 member D-like; MMR; CLEC13DL; CD206; Macrophage mannose receptor 1; bA541I19.1; CD antigen CD206; MRC1L1

Application Instructions

Application Suggestion
Tested Application Dilution
FACS10 µl / 10^6 cells
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Buffer PBS and 15 mM Sodium azide
Preservative 15 mM Sodium azide
Storage Instruction Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 17533 Mouse MRC1

GeneID: 4360 Human MRC1

Swiss-port # P22897 Human Macrophage mannose receptor 1

Swiss-port # Q61830 Mouse Macrophage mannose receptor 1

Gene Symbol MRC1
Gene Full Name mannose receptor, C type 1
Background The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. CD206 / MMR is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. [provided by RefSeq, Sep 2015]
Function CD206 / MMR mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.

(Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens.

(Microbial infection) Acts as a receptor for Dengue virus envelope protein E.

(Microbial infection) Interacts with Hepatitis B virus envelope protein. [UniProt]
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Research Area Immune System antibody; M1/M2/TAM Marker antibody; Macrophage Marker antibody; M2 Macrophage Marker antibody
Calculated MW 166 kDa