ARG43453

anti-CD206 / MMR antibody

anti-CD206 / MMR antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse

Immune System antibody; M1/M2/TAM Marker antibody; Macrophage Marker antibody; M2 Macrophage Marker antibody

Overview

Product Description Rabbit Polyclonal antibody recognizes CD206 / MMR
Tested Reactivity Hu, Ms
Predict Reactivity Rat
Tested Application FACS, IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name CD206 / MMR
Antigen Species Human
Immunogen Recombinant fusion protein corresponding to a.a. 21-1140 of Human CD206 / MMR.
Conjugation Un-conjugated
Protein Full Name Macrophage mannose receptor 1
Alternate Names CLEC13D; C-type lectin domain family 13 member D; Macrophage mannose receptor 1-like protein 1; C-type lectin domain family 13 member D-like; MMR; CLEC13DL; CD206; Macrophage mannose receptor 1; bA541I19.1; CD antigen CD206; MRC1L1

Application Instructions

Application Suggestion
Tested Application Dilution
FACS1-3 µg / 1 X 10^6 cells
IHC-P0.5 - 1 µg/ml
WB0.25-0.5 µg/ml
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control HEK293, RAW264.7
Observed Size ~185 kDa

Properties

Form Liquid
Purification Affinity purification with immunogen.
Buffer 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 4% Trehalose.
Preservative 0.05% Sodium azide
Stabilizer 4% Trehalose
Concentration 0.5 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 17533 Mouse MRC1

GeneID: 4360 Human MRC1

Swiss-port # P22897 Human Macrophage mannose receptor 1

Swiss-port # Q61830 Mouse Macrophage mannose receptor 1

Gene Symbol MRC1
Gene Full Name mannose receptor, C type 1
Background The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. CD206 / MMR is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. [provided by RefSeq, Sep 2015]
Function CD206 / MMR mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.

(Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens.

(Microbial infection) Acts as a receptor for Dengue virus envelope protein E.

(Microbial infection) Interacts with Hepatitis B virus envelope protein. [UniProt]
Cellular Localization Endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. [UniProt]
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Research Area Immune System antibody; M1/M2/TAM Marker antibody; Macrophage Marker antibody; M2 Macrophage Marker antibody
Calculated MW 166 kDa
PTM Disulfide bond, Glycoprotein