ARG21136
anti-CD21 antibody [BB6-11C9.6] (Biotin)
anti-CD21 antibody [BB6-11C9.6] (Biotin) for Flow cytometry,IHC-Frozen sections and Pig
Overview
| Product Description | Biotin-conjugated Mouse Monoclonal antibody [BB6-11C9.6] recognizes CD21 |
|---|---|
| Tested Reactivity | Pig |
| Tested Application | FACS, IHC-Fr |
| Specificity | Porcine CD21. The clone BB6-11C9.6 stains the following percentages of surface immunoglobulin (sIg) positive cells in porcine lymphoid tissues - 92-96% in peripheral blood, 74-98% in mesenteric lymph nodes, 97-100% in ileal Peyer’s patches (ILPP), 93-97% in spleen, and 0% in thymus. The antibody does not stain B cells in cord blood or spleen from pig fetuses (105 days gestation). |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | BB6-11C9.6 |
| Isotype | IgG1, kappa |
| Target Name | CD21 |
| Antigen Species | Pig |
| Conjugation | Biotin |
| Alternate Names | Cr2; Complement C3d receptor; C3DR; CD21; CD antigen CD21; Complement receptor type 2; SLEB9; CR; CVID7; Epstein-Barr virus receptor; EBV receptor |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Buffer | PBS and 0.1% Sodium azide. |
| Preservative | 0.1% Sodium azide |
| Concentration | 0.5 mg/ml |
| Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | CR2 |
|---|---|
| Gene Full Name | complement component (3d/Epstein Barr virus) receptor 2 |
| Background | CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands. |
| Function | Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation. [UniProt] |
| Calculated MW | 113 kDa |
