ARG66930
anti-CD223 / LAG3 antibody [SQab22258]
anti-CD223 / LAG3 antibody [SQab22258] for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Recombinant Rabbit Monoclonal antibody [SQab22258] recognizes CD223 / LAG3 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | SQab22258 |
| Isotype | IgG |
| Target Name | CD223 / LAG3 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide within Human LAG-3. |
| Conjugation | Un-conjugated |
| Protein Full Name | Lymphocyte activation gene 3 protein |
| Alternate Names | CD antigen CD223; CD223; Protein FDC; Lymphocyte activation gene 3 protein; LAG-3 |
Application Instructions
| Application Suggestion |
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| Application Note | IHC-P: Antigen Retrieval: Heat mediated was performed using Tris/EDTA buffer (pH 9.0). Incubate the samples at RT (18-25°C) for 37 min. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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| Positive Control | Human lymphoma tissue |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A. |
| Buffer | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05%BSA. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 40% Glycerol and 0.05%BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P18627 Human Lymphocyte activation gene 3 protein |
|---|---|
| Gene Symbol | LAG3 |
| Gene Full Name | lymphocyte-activation gene 3 |
| Background | Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008] |
| Function | Involved in lymphocyte activation. Binds to HLA class-II antigens. [UniProt] |
| Cellular Localization | Membrane, Single-pass type I membrane protein. [UniProt] |
| Calculated MW | 57 kDa |
