ARG63963

anti-CD230 / Prion protein antibody

anti-CD230 / Prion protein antibody for Western blot and Human

Developmental Biology antibody; Neuroscience antibody

Overview

Product Description Goat Polyclonal antibody recognizes CD230 / Prion protein
Tested Reactivity Hu
Predict Reactivity Cow, Pig
Tested Application WB
Specificity Reported variants represent identical protein (NP_000302.1; NP_898902.1; NP_001073590.1; NP_001073591.1; NP_001073592.1).
Host Goat
Clonality Polyclonal
Isotype IgG
Target Name CD230 / Prion protein
Antigen Species Human
Immunogen C-SDYEDRYYREN
Conjugation Un-conjugated
Alternate Names GSS; PrPc; PrP33-35C; PrP27-30; Alternative prion protein; p27-30; CJD; ASCR; CD230; PrP; PRIP; KURU; AltPrP

Application Instructions

Application Suggestion
Tested Application Dilution
WB0.3 - 1 µg/ml
Application Note WB: Recommend incubate at RT for 1h.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Buffer Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA
Preservative 0.02% Sodium azide
Stabilizer 0.5% BSA
Concentration 0.5 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 5621 Human PRNP

Swiss-port # F7VJQ1 Human Alternative prion protein

Background The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Research Area Developmental Biology antibody; Neuroscience antibody
Calculated MW 9 kDa
PTM The glycosylation pattern (the amount of mono-, di- and non-glycosylated forms or glycoforms) seems to differ in normal and CJD prion.
Isoform 2 is sumoylated with SUMO1.