ARG54418
anti-CD253 / TRAIL antibody
anti-CD253 / TRAIL antibody for Western blot,ICC/IF and Human
Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody
Overview
Product Description | Rabbit Polyclonal antibody recognizes CD253 / TRAIL |
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Tested Reactivity | Hu |
Tested Application | ICC/IF, WB |
Specificity | This antibody recognizes human TRAIL. |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Target Name | CD253 / TRAIL |
Antigen Species | Human |
Immunogen | Synthetic peptide corresponding to aa 261-277 of human TRAIL (accession no. NP_003801). |
Conjugation | Un-conjugated |
Alternate Names | TL2; CD253; Protein TRAIL; TNF-related apoptosis-inducing ligand; TRAIL; CD antigen CD253; Apo-2 ligand; Apo-2L; APO2L; Tumor necrosis factor ligand superfamily member 10 |
Application Instructions
Application Suggestion |
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Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
Positive Control | HeLa and Human brain |
Properties
Form | Liquid |
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Purification | Immunoaffinity chroma-tography |
Buffer | PBS (pH 7.4) and 0.02% Sodium azide |
Preservative | 0.02% Sodium azide |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links |
Swiss-port # P50591 Human Tumor necrosis factor ligand superfamily member 10 |
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Gene Symbol | TNFSF10 |
Gene Full Name | tumor necrosis factor (ligand) superfamily, member 10 |
Background | Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain-containing receptors, TNFR1 and Fas. A novel member of the TNF family has been identified and designated TRAIL (TNF-related apoptosis-inducing ligand) and Apo-2L (Apo-2 ligand). TRAIL is a type II membrane protein and expressed in a variety of human tissues. Two novel death domain-containing receptors, DR4 and DR5, have been identified as the receptor for TRAIL. Like TNF and Fas ligand, TRAIL induces apoptosis and NF- B activation in many tissues and cell types. |
Function | Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. [UniProt] |
Research Area | Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody |
Calculated MW | 33 kDa |
PTM | Tyrosine phosphorylated by PKDCC/VLK. |