ARG23336

anti-CD253 / TRAIL antibody [B-S23] (PE)

anti-CD253 / TRAIL antibody [B-S23] (PE) for Flow cytometry and Human

Overview

Product Description PE-conjugated Mouse Monoclonal antibody [B-S23] recognizes CD253 / TRAIL
Tested Reactivity Hu
Tested Application FACS
Specificity This antibody recognizes the TRAIL, APO2L antigen, a 32 kDa protein.
Host Mouse
Clonality Monoclonal
Clone B-S23
Isotype IgG1
Target Name CD253 / TRAIL
Antigen Species Human
Immunogen Recombinant human TRAIL
Conjugation PE
Alternate Names TL2; CD253; Protein TRAIL; TNF-related apoptosis-inducing ligand; TRAIL; CD antigen CD253; Apo-2 ligand; Apo-2L; APO2L; Tumor necrosis factor ligand superfamily member 10

Application Instructions

Application Suggestion
Tested Application Dilution
FACSAssay-dependent
Application Note FACS: Use 10 µl to label 10^6 cells or 100 µl of whole blood.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Buffer PBS, 0.1% Sodium azide and 5% BSA.
Preservative 0.1% Sodium azide
Stabilizer 5% BSA
Storage Instruction Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 8743 Human TNFSF10

Swiss-port # P50591 Human Tumor necrosis factor ligand superfamily member 10

Gene Symbol TNFSF10
Gene Full Name tumor necrosis factor (ligand) superfamily, member 10
Background The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Function Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. [UniProt]
Calculated MW 33 kDa
PTM Tyrosine phosphorylated by PKDCC/VLK. [UniProt]