ARG54397

anti-CD261 / TRAIL R1 antibody

anti-CD261 / TRAIL R1 antibody for Western blot,ICC/IF and Human

Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody

Overview

Product Description Rabbit Polyclonal antibody recognizes CD261 / TRAIL R1
Tested Reactivity Hu
Tested Application ICC/IF, WB
Specificity This antibody recognizes full-length human DR4 (57kDa).
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name CD261 / TRAIL R1
Antigen Species Human
Immunogen Peptide around aa. 427-445 (C-terminus) of human DR4 protein (accession no. ACC51226).
Conjugation Un-conjugated
Alternate Names TNF-related apoptosis-inducing ligand receptor 1; CD antigen CD261; TRAILR-1; DR4; Tumor necrosis factor receptor superfamily member 10A; CD261; Death receptor 4; APO2; TRAIL receptor 1; TRAIL-R1; TRAILR1

Application Instructions

Application Suggestion
Tested Application Dilution
ICC/IFAssay-dependent
WBAssay-dependent
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control HeLa and Jurkat

Properties

Form Liquid
Purification Immunoaffinity chroma-tography
Buffer PBS (pH 7.4) and 0.02% Sodium azide
Preservative 0.02% Sodium azide
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 8797 Human TNFRSF10A

Swiss-port # O00220 Human Tumor necrosis factor receptor superfamily member 10A

Gene Symbol TNFRSF10A
Gene Full Name tumor necrosis factor receptor superfamily, member 10a
Background Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain-containing receptors, TNFR1 and Fas. Another cell death receptor was recently identified and designated DR4. The ligand for DR4 has been designated TRAIL and is a new member of the TNF family. Therefore, DR4 is also called TRAIL receptor-1. DR4 is expressed in most human tissues including spleen, peripheral blood, small intestine, and thymus. Like TNFR1, Fas and DR3, DR4 mediates TRAIL-induced apoptosis and NF-B activation in many tissues and cells.
Function Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. [UniProt]
Research Area Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody
Calculated MW 50 kDa