ARG54125

anti-CD262 / TRAIL R2 antibody

anti-CD262 / TRAIL R2 antibody for Western blot,ICC/IF and Human,Mouse

Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Signaling Transduction antibody

Overview

Product Description Mouse Monoclonal antibody recognizes CD262 / TRAIL R2
Tested Reactivity Hu, Ms
Tested Application ICC/IF, WB
Host Mouse
Clonality Monoclonal
Isotype IgG1
Target Name CD262 / TRAIL R2
Antigen Species Human
Immunogen Purified recombinant human DR5 protein fragments expressed in E.coli.
Conjugation Un-conjugated
Alternate Names TRICK2A; TRICK2B; KILLER; TRAILR2; TNF-related apoptosis-inducing ligand receptor 2; DR5; CD antigen CD262; TRICK2; CD262; KILLER/DR5; Tumor necrosis factor receptor superfamily member 10B; Death receptor 5; TRAIL-R2; TRAIL receptor 2; TRICKB; ZTNFR9

Application Instructions

Application Suggestion
Tested Application Dilution
ICC/IF1:100
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Observed Size 48 kDa

Properties

Form Liquid
Purification Affinity purified
Buffer PBS (pH 7.4), 0.02% Sodium azide, 0.1mg/ml BSA and 50% Glycerol
Preservative 0.02% Sodium azide
Stabilizer 0.1mg/ml BSA, 50% Glycerol
Concentration 0.4 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 21933 Mouse TNFRSF10B

GeneID: 8795 Human TNFRSF10B

Swiss-port # O14763 Human Tumor necrosis factor receptor superfamily member 10B

Swiss-port # Q9QZM4 Mouse Tumor necrosis factor receptor superfamily member 10B

Gene Symbol TNFRSF10B
Gene Full Name tumor necrosis factor receptor superfamily, member 10b
Background Receptor for the cytotoxic ligand TNFSF10/TRAIL.The adapter molecule FADD recruits caspase-8 to the activated receptor.The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.Essential for ER stress-induced apoptosis.
Function Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. [UniProt]
Cellular Localization Membrane; Single-pass type I membrane protein.
Research Area Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Signaling Transduction antibody
Calculated MW 48 kDa