ARG53809
anti-CD263 / TRAIL R3 antibody [TRAIL-R3-02] (PE)
anti-CD263 / TRAIL R3 antibody [TRAIL-R3-02] (PE) for Flow cytometry and Human
Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody
Overview
| Product Description | PE-conjugated Mouse Monoclonal antibody [TRAIL-R3-02] recognizes CD263 / TRAIL R3 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS |
| Specificity | The clone TRAIL-R3-02 reacts with TRAIL-R3, a 35 kDa GPI-anchored extracellular membrane protein expressed mainly on neutrophils. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | TRAIL-R3-02 |
| Isotype | IgG1 |
| Target Name | CD263 / TRAIL R3 |
| Immunogen | TRAIL-R3 (aa 1-280) - hIgGhc fusion protein |
| Conjugation | PE |
| Alternate Names | Lymphocyte inhibitor of TRAIL; Antagonist decoy receptor for TRAIL/Apo-2L; TNF-related apoptosis-inducing ligand receptor 3; DCR1; TRID; CD antigen CD263; Tumor necrosis factor receptor superfamily member 10C; CD263; Decoy TRAIL receptor without death domain; LIT; Decoy receptor 1; DcR1; DCR1-TNFR; TRAIL-R3; TRAIL receptor 3; TRAILR3; TRAIL receptor without an intracellular domain |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification Note | The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography. |
| Buffer | PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA |
| Preservative | 15 mM Sodium azide |
| Stabilizer | 0.2% (w/v) high-grade protease free BSA |
| Concentration | 0.1 mg/ml |
| Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O14798 Human Tumor necrosis factor receptor superfamily member 10C |
|---|---|
| Gene Symbol | TNFRSF10C |
| Gene Full Name | tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain |
| Background | TRAIL-R3 (CD263, TR3, DcR1, LIT, TRID), expressed mainly on neutrophils, belongs to receptors of TRAIL, a TNF-like membrane cytotoxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R3, however, is a GPI-anchored protein that lacks cytoplasmic death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by competing for binding of TRAIL with death receptor 5 (DR5). |
| Function | Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand. [UniProt] |
| Research Area | Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody |
| Calculated MW | 27 kDa |
| PTM | N-glycosylated and O-glycosylated. |
