ARG54410
anti-CD264 / TRAIL R4 antibody
anti-CD264 / TRAIL R4 antibody for ICC/IF,Western blot and Human
Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CD264 / TRAIL R4 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ICC/IF, WB |
| Specificity | This antibody recognizes full-length DcR2 (34kDa). |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CD264 / TRAIL R4 |
| Antigen Species | Human |
| Immunogen | Peptide corresponding to aa 249-263 of human DcR2 precursor (accession no. Q9UBN6). |
| Conjugation | Un-conjugated |
| Alternate Names | Tumor necrosis factor receptor superfamily member 10D; CD264; DCR2; CD antigen CD264; DcR2; Decoy receptor 2; TNF-related apoptosis-inducing ligand receptor 4; TRUNDD; TRAILR4; TRAIL receptor with a truncated death domain; TRAIL receptor 4; TRAIL-R4 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | HeLa |
Properties
| Form | Liquid |
|---|---|
| Purification | Immunoaffinity chroma-tography |
| Buffer | PBS (pH 7.4) and 0.02% Sodium azide |
| Preservative | 0.02% Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9UBN6 Human Tumor necrosis factor receptor superfamily member 10D |
|---|---|
| Gene Symbol | TNFRSF10D |
| Gene Full Name | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain |
| Background | TRAIL/Apo2L is a new member of the TNF family and induces apoptosis in a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a "decoy receptor". Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD. DcR2 has an extracellular TRAIL-binding domain but lacks an intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuates TRAIL-induced apoptosis. |
| Function | Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway. [UniProt] |
| Research Area | Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody |
| Calculated MW | 42 kDa |
