ARG53811

anti-CD264 / TRAIL R4 antibody [TRAIL-R4-01] (PE)

anti-CD264 / TRAIL R4 antibody [TRAIL-R4-01] (PE) for Flow cytometry and Human

Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody

Overview

Product Description PE-conjugated Mouse Monoclonal antibody [TRAIL-R4-01] recognizes CD264 / TRAIL R4
Tested Reactivity Hu
Tested Application FACS
Specificity The clone TRAIL-R4-01 reacts with TRAIL-R4, a 42 kDa transmembrane protein expressed on various blood cells.
Host Mouse
Clonality Monoclonal
Clone TRAIL-R4-01
Isotype IgG1
Target Name CD264 / TRAIL R4
Immunogen TRAIL-R4 (aa 1-210) - hIgGhc fusion protein
Conjugation PE
Alternate Names Tumor necrosis factor receptor superfamily member 10D; CD264; DCR2; CD antigen CD264; DcR2; Decoy receptor 2; TNF-related apoptosis-inducing ligand receptor 4; TRUNDD; TRAILR4; TRAIL receptor with a truncated death domain; TRAIL receptor 4; TRAIL-R4

Application Instructions

Application Suggestion
Tested Application Dilution
FACS2 - 5 µg/ml
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Note The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Buffer PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA
Preservative 15 mM Sodium azide
Stabilizer 0.2% (w/v) high-grade protease free BSA
Concentration 0.1 mg/ml
Storage Instruction Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 8793 Human TNFRSF10D

Swiss-port # Q9UBN6 Human Tumor necrosis factor receptor superfamily member 10D

Gene Symbol TNFRSF10D
Gene Full Name tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
Background TRAIL-R4 (CD264, TR4, DcR2, TRUNDD), expressed mainly on CD8+ and NK cells, belongs to receptors of TRAIL, a TNF-like membrane toxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4, however, contains partially truncated death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing. TRAIL-R4 interacts with death receptor 5 (DR5) in the native DISC in a TRAIL-dependent manner and prevents its corecruitment with death receptor 4 (DR4).
Function Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway. [UniProt]
Research Area Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody
Calculated MW 42 kDa