ARG42421
anti-CD267 / TACI antibody [1A1] (APC)
anti-CD267 / TACI antibody [1A1] (APC) for Flow cytometry and Human
Overview
Product Description | APC-conjugated Rat Monoclonal antibody [1A1] recognizes CD267 / TACI |
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Tested Reactivity | Hu |
Tested Application | FACS |
Specificity | The rat monoclonal antibody 1A1 recognizes an extracellular epitope of CD267 / TACI, a 32 kDa type III transmembrane protein expressed by B cells and possibly by some activated T cells. |
Host | Rat |
Clonality | Monoclonal |
Clone | 1A1 |
Isotype | IgG |
Target Name | CD267 / TACI |
Antigen Species | Human |
Immunogen | CD267-transfected RBL cells. |
Conjugation | APC |
Alternate Names | Tumor necrosis factor receptor superfamily member 13B; Transmembrane activator and CAML interactor; TNFRSF14B; IGAD2; CD267; RYZN; TACI; CD antigen CD267; CVID; CVID2 |
Application Instructions
Application Suggestion |
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Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
Form | Liquid |
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Purification | Purified |
Buffer | PBS and 15 mM Sodium azide. |
Preservative | 15 mM Sodium azide |
Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links |
Swiss-port # O14836 Human Tumor necrosis factor receptor superfamily member 13B |
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Gene Symbol | TNFRSF13B |
Gene Full Name | tumor necrosis factor receptor superfamily, member 13B |
Background | The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008] |
Function | Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. [UniProt] |
Cellular Localization | Membrane; Single-pass type III membrane protein. [UniProt] |
Calculated MW | 32 kDa |