ARG42421

anti-CD267 / TACI antibody [1A1] (APC)

anti-CD267 / TACI antibody [1A1] (APC) for Flow cytometry and Human

Overview

Product Description APC-conjugated Rat Monoclonal antibody [1A1] recognizes CD267 / TACI
Tested Reactivity Hu
Tested Application FACS
Specificity The rat monoclonal antibody 1A1 recognizes an extracellular epitope of CD267 / TACI, a 32 kDa type III transmembrane protein expressed by B cells and possibly by some activated T cells.
Host Rat
Clonality Monoclonal
Clone 1A1
Isotype IgG
Target Name CD267 / TACI
Antigen Species Human
Immunogen CD267-transfected RBL cells.
Conjugation APC
Alternate Names Tumor necrosis factor receptor superfamily member 13B; Transmembrane activator and CAML interactor; TNFRSF14B; IGAD2; CD267; RYZN; TACI; CD antigen CD267; CVID; CVID2

Application Instructions

Application Suggestion
Tested Application Dilution
FACS10 µl / 100 µl of whole blood or 10^6 cells
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purified
Buffer PBS and 15 mM Sodium azide.
Preservative 15 mM Sodium azide
Storage Instruction Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 23495 Human TNFRSF13B

Swiss-port # O14836 Human Tumor necrosis factor receptor superfamily member 13B

Gene Symbol TNFRSF13B
Gene Full Name tumor necrosis factor receptor superfamily, member 13B
Background The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Function Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. [UniProt]
Cellular Localization Membrane; Single-pass type III membrane protein. [UniProt]
Calculated MW 32 kDa